Phenanthrenes and derivatives
Medchemexpress LLC Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 200 MG
Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 200 MG
eMolecules Chem-Impex Malonic acid anhydrous 25kg 272385283 02873 0 000 141-82-2 104 061 C3H4O4
Chem-Impex Malonic acid anhydrous 25kg 272385283 02873 0 000 141-82-2 104 061 C3H4O4
Medchemexpress LLC Vardenafil hydrochloride | 224785-91-5 | 99.8% | 200 MG
Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM, showing lower inhibition of PDE1, PDE6, PDE3, and PDE4. It competitively inhibits cGMP hydrolysis, leading to increased cGMP levels. It is used for research of erectile dysfunction, hepatitis, and diabetes.
- Specifically inhibits cGMP hydrolysis by PDE5, increasing intracellular cGMP levels for increased dilation and blood flow.
- Exhibits facilitator effects in rats with cavernous nerve injury.
- Protects the liver against Con A-induced hepatitis in mice and decreases NF-κB expression.
- Prevents reduction of tissue cGMP levels and increased 3-NT generation in ZDF hearts.
Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 99.7% | 200 MG
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It shows inhibitory effects towards PDE1 and PDE6 with IC50s of 180 nM and 11 nM, respectively, while IC50s are >1000 nM for PDE3 and PDE4. It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, which increases cGMP levels. It can be used for research related to erectile dysfunction, hepatitis, and diabetes.
- It is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5).
- It has an IC50 of 0.7 nM for PDE5.
- It inhibits PDE1 and PDE6 with IC50s of 180 nM and 11 nM.
- It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis.
- It increases cGMP levels.
- It can be used for the research of erectile dysfunction.
- It can be used for the research of hepatitis.
- It can be used for the research of diabetes.
Cayman Chemical ArIstolochIc AcId 50mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas
Medchemexpress LLC Methacycline hydrochloride | 3963-95-9 | 99.3% | 200 MG
Methacycline hydrochloride is a tetracycline antibiotic that inhibits bacterial protein synthesis. It is also a potent epithelial-mesenchymal transition (EMT) inhibitor, blocking EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. This compound is an antimicrobial and has potential for pulmonary fibrosis.
- Inhibits bacterial protein synthesis
- Acts as a potent epithelial-mesenchymal transition (EMT) inhibitor
- Blocks EMT in vitro and fibrogenesis in vivo
- Demonstrates antimicrobial properties
- Shows potential for pulmonary fibrosis treatment
- Inhibits A549 EMT with an IC50 of approximately 5 μM
- Attenuates Bleomycin-induced canonical EMT markers
- Improves survival at Day 17 in vivo studies
![eMolecules ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475670.JPG-250.jpg)
eMolecules ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6
ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6
Medchemexpress LLC 6-aminochrysene | 2642-98-0 | MFCD00003699 | 99.7% | 243.30 g/mol | C18H13N | 50 MG
6-Aminochrysene is an aromatic amine research compound (CAS 2642-98-0) used in laboratory studies. The light yellow solid has molecular formula C18H13N and a molecular weight of 243.30 g/mol. The supplier lists high purity, DMSO solubility data, storage recommendations for powder and solutions, and multiple small pack sizes for research use.
- Light yellow to yellow solid appearance.
- Molecular formula C18H13N and molecular weight 243.30 g/mol.
- High purity (99.7%).
- Soluble in DMSO (100 mg/mL); sonication recommended.
- Recommended storage conditions provided for powder and in-solution forms.
- Available in small research pack sizes, including 50 mg.
Medchemexpress LLC Dasatinib hydrochloride | 854001-07-3 | 99.3% | 524.5 g·mol⁻¹ | C22H27Cl2N7O2S | 200 MG
Dasatinib hydrochloride is a research-grade, ATP-competitive dual Src and Bcr-Abl kinase inhibitor supplied as the hydrochloride salt. It exhibits subnanomolar to low-nanomolar activity against its targets and is intended for laboratory and preclinical research applications; supplied at high purity for analytical use.
- High purity: 99.31%.
- Potent dual Src and Bcr-Abl inhibition at subnanomolar to low-nanomolar concentrations.
- Supplied as the hydrochloride salt in solid form for research use.
- Suitable for research and analytical applications; not for human consumption.
- Available in multiple pack sizes, including 200 MG.
Medchemexpress LLC 6-Aminochrysene | 2642-98-0 | MFCD00003699 | 99.7% | 243.30 g/mol | C18H13N | 100 MG
6-Aminochrysene is an aromatic amine used in biochemical and toxicological research. The compound is supplied as a high-purity solid or as DMSO solutions for laboratory assays and analytical studies.
- High purity of 99.7% for accurate analytical results.
- Molecular formula C18H13N and molecular weight 243.30 g/mol.
- Available in small research quantities, including 100 mg and solution formats.
- Applicable to enzymatic metabolism, mutagenicity, and toxicology studies.
- Provided with purity and identity information appropriate for research use.
AdipoGen Hypericin
Chemical. CAS 548-04-9. Formula C30H16O8. MW 504.5. Isolated from Hypericum perforatum. One of the principal active constituents of St. Johns Wort Hypericum perforatum. Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission lambdamax 594nm. Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses including HIV. This photosensitizing agent has shown to induce apoptosis and necrosis in cancer cells during photodynamic therapy. Selective inhibitor of protein kinase C PKC. Has been shown to inhibit other kinases and targets such as EGFR-PTK, PI3K, CKII, MAPK and insulin receptor IR. Necrosis-avid contrast agent investigated for use in non-invasively targeting necrotic tissues, based on to be defined components in the phospholipid bilayer.
Medchemexpress LLC Docosahexaenoic acid | 6217-54-5 | 98.8% | 200 MG
Docosahexaenoic acid (DHA) is an omega-3 fatty acid abundantly present in the brain and retina, crucial for development and maintaining normal function. Obtained from fish oil and maternal milk, DHA plays a vital role in cognitive abilities and neurological health.
- Essential for infant brain growth and functional development
- Maintains normal adult brain function
- Improves learning ability and memory
- Required for neural cell proliferation, migration, differentiation, and synaptogenesis
- Unique structure supports effective cell signaling
- Potent RXR ligand, activating RXRα at low micromolar concentrations
- Reduces reference memory errors
- Increases DHA content and DHA/arachidonic acid ratio in brain regions
- Exhibits neuroprotective actions in Parkinson's disease models