Phenanthrenes and derivatives
Apexbio Technology LLC FOSFRUCTOSE-TRISODIUM-200MG
Fosfructose trisodium (CAS No 38099-82-0) is a compound studied in the field of biomedical research primarily for its role in energy metabolism pathways Originating from biochemical applications it influences fructose metabolism by acting on glycolysis and gluconeogenesis pathways potentially modifying cellular energy balance In vitro studies have demonstrated activity in the nanomolar to low micromolar range highlighting its potency in modulating metabolic enzymes Its typical applications include investigations using cell models and animal studies to determine its effects on metabolic disorders and it is also utilized in drug screening processes for targeting metabolic pathways Experimental concentrations typically depend on the specific research design adapting to the precise requirements of each study to elucidate its effects comprehensively
Medchemexpress LLC Hypericin (Standard) | 548-04-9 | 504.44 | 5 MG
Hypericin (Standard) is an analytical standard intended for research and analytical applications. This naturally occurring substance, found in Hypericum perforatum L., acts as an inhibitor of several enzymes including PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP. It demonstrates antitumor, antiviral, and antidepressive activities, and can induce apoptosis. It is widely used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Naturally occurring substance from Hypericum perforatum L.
- Inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP
- Exhibits antitumor, antiviral, and antidepressive activities
- Can induce apoptosis
- Used in HPLC, GC, and MS experiments
eMolecules 141-82-2 | Malonic acid | Oakwood Chemical104.061 | C3H4O4 | 99.000 | OC(=O)CC(O)=O | 25g | 537678611
Malonic acid | Oakwood Chemical | 141-82-2104.061 | C3H4O4 | 99.000 | OC(=O)CC(O)=O | 25g | 537678611
eMolecules 141-82-2 | Malonic acid | Oakwood Chemical104.061 | C3H4O4 | 99.000 | OC(=O)CC(O)=O | 5g | 537678610
Malonic acid | Oakwood Chemical | 141-82-2104.061 | C3H4O4 | 99.000 | OC(=O)CC(O)=O | 5g | 537678610
Medchemexpress LLC Irinotecan hydrochloride trihydrate | 136572-09-3 | 99.9% | 200 MG
Irinotecan hydrochloride trihydrate is a potent topoisomerase I inhibitor known for its antitumor activity. It targets Topoisomerase I, playing a crucial role in cancer research and drug development.
- Inhibits the growth of LoVo and HT-29 cells.
- Suppresses the proliferation of human umbilical vein endothelial cells (HUVEC).
- Significantly inhibits tumor growth in various in vivo models.
- Shows effectiveness against HT-29 xenografts.
Medchemexpress LLC Fullerene-C60-Ih (9CI, ACI) | 99685-96-8 | MFCD00151408 | 99.7% | 720.64 g·mol⁻¹ | C60 | 100 MG
Fullerene-C60 (C60) is a high-purity carbon nanomaterial (buckminsterfullerene) used in photophysical and biochemical research. It serves as an effective electron acceptor and radical scavenger, and efficiently produces singlet oxygen upon light excitation, making it useful for photodynamic studies and electron-transfer experiments.
- High purity suitable for laboratory research.
- Efficient singlet oxygen generation under UV/visible light.
- Strong electron-accepting and radical-scavenging properties.
- Available in small pack sizes for experimental flexibility.
- Well-characterized molecular weight and composition.
Medchemexpress LLC Hypericin (Standard) | 548-04-9 | 504.44 | 50 MG
Hypericin (Standard) is the analytical standard of Hypericin, a naturally occurring substance found in *Hypericum perforatum L*. It acts as an inhibitor of various biological targets and exhibits antitumor, antiviral, and antidepressive activities. This analytical standard is intended for research and analytical applications.
- Used as a reference standard for assay
- Utilized in qualitative research experiments
- Utilized in quantitative research experiments
- Utilized in methodological research experiments involving HPLC, GC, and MS
Medchemexpress LLC Aristolochic acid Va | 108779-46-0 | 357.27 | 5 MG
Aristolochic acid Va is a natural compound that can be isolated from Aristolochia plants. It is for research use only and not sold to patients.
- Purity: 98.74%
- Appearance: Solid
- Color: Light yellow to yellow
- Initial source: Plants Aristolochiaceae Aristolochia debilis Sieb. et Zucc.
Medchemexpress LLC Hypericin | 548-04-9 | 504.5 | 1 ML
Hypericin is a naturally occurring substance found in *Hyperlcurn perforatum L.* It acts as an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP (cytochrome P450).
- Demonstrates antitumor activity.
- Exhibits antiviral activity.
- Shows antidepressive activities.
- Can induce apoptosis.
Medchemexpress LLC Piperidolate hydrochloride | 129-77-1 | 99.66% | 200 MG
Piperidolate hydrochloride is an antimuscarinic agent that inhibits intestinal cramps induced by acetylcholine in rats and dogs. This compound is intended for research use only.
- Antimuscarinic agent
- Inhibits intestinal cramps
- Research use only
- White to off-white solid appearance
Medchemexpress LLC AM095 free acid | 1228690-36-5 | 99.0% | 456.49 | 200 MG
AM095 free acid is a potent LPA1 receptor antagonist that effectively inhibits LPA-induced calcium flux in CHO cells transfected with human or mouse LPA1. It also significantly reduces LPA-induced vasorelaxation and inhibits LPA-driven chemotaxis in various cell types. In preclinical studies, it has shown to attenuate bleomycin-induced dermal fibrosis and decrease kidney fibrosis in a mouse model of unilateral ureteral obstruction. The compound exhibits high oral bioavailability, a moderate half-life, and is well tolerated in animal models.
- Potent LPA1 receptor antagonist.
- Inhibits LPA-induced calcium flux in CHO cells.
- Reduces LPA-induced vasorelaxation.
- Inhibits LPA-driven chemotaxis in melanoma cells.
- Attenuates bleomycin-induced dermal fibrosis in vivo.
- Decreases kidney fibrosis in a mouse model.
- High oral bioavailability.
- Moderate half-life.
- Well tolerated in rats and dogs.
Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 200 MG
Pexidartinib hydrochloride is a potent, orally active, selective, and ATP-competitive inhibitor of colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit. This compound induces cell apoptosis and demonstrates anti-cancer activity.
- Potent, orally active, selective, and ATP-competitive inhibitor.
- Targets colony stimulating factor 1 receptor (CSF1R) and c-Kit.
- Exhibits high selectivity over other related kinases.
- Induces cell apoptosis and demonstrates anti-cancer activity.
- IC50 of 10 nM for c-Kit and 20 nM for cFMS.
Cayman Chemical Aristolochic Acid, Purity: ≥98%, CAS: 313-67-7, 100 mg
A PLA2 inhibitor (IC50 = 40 µM in human neutrophils); inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo; inhibits hemolytic activity of the PLA2 enzymes TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively); enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib; associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas